Aptamers: A promising chemical antibody for cancer therapy
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چکیده
منابع مشابه
Aptamers: A promising chemical antibody for cancer therapy
Aptamers, also known as chemical antibodies, are single-stranded nucleic acid oligonucleotides which bind to their targets with high specificity and affinity. They are typically selected by repetitive in vitro process termed systematic evolution of ligands by exponential enrichment (SELEX). Owing to their excellent properties compared to conventional antibodies, notably their smaller physical s...
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Aptamers are single-stranded DNA or RNA oligonucleotides or peptides that are capable of binding to specific target proteins. Aptamers are generated in a process named SELEX or cell-SELEX. They resemble antigens in respect of their highly specific binding in the lower nanomolar and/or picomolar range. In contrast to antibodies, they can be generated in vitro, are more stable molecules and have ...
متن کاملGenerating Aptamers for Cancer Diagnosis and Therapy
Aptamers are single-stranded DNA or RNA oligonucleotides or peptides that are capable of binding to specific target proteins. Aptamers are generated in a process named SELEX or cell-SELEX. They resemble antigens in respect of their highly specific binding in the lower nanomolar and/or picomolar range. In contrast to antibodies, they can be generated in vitro, are more stable molecules and have ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.7178